Effect of SARS-CoV-2 Infection and COVID-19 Vaccination on Oxidative Status of Human Placenta: A Preliminary Study

Infection with SARS-CoV-2 during pregnancy increases the risk of complications associated inflammation, which could lead to oxidative stress in placenta. Whether vaccination against COVID-19 has any effect is unclear. This study aimed analyze effects infection and on placenta extracellular DNA (ecDNA) umbilical cord plasma. Placenta samples from healthy uninfected unvaccinated control patients who recovered women vaccinated were collected. Biomarkers damage antioxidant capacity assessed homogenates. EcDNA deoxyribonuclease activity quantified plasma using real-time PCR single radial enzyme diffusion method, respectively. Markers lipids proteins as well did not differ between groups. No differences observed total, nuclear or mitochondrial ecDNA, Taking into account limits a small observational study, our results suggest that do induce major disturbances balance production free radicals line minor fetal outcomes ecDNA suggested marker well-being.